Repeated exposure to anesthesia and surgery before the age of 2 years was a significant independent risk factor for the later development of learning disabilities in a matched cohort study involving children in one school district, adjustment for comorbidity, and multiple outcome measures.
No association was seen after a single episode of anesthesia and surgery, according to Dr. Randall P. Flick and his colleagues at the Mayo Clinic in Rochester, Minn.
In the past decade, animal studies have firmly established a relationship between the use of general anesthetics during periods of rapid brain growth and widespread apoptotic neurodegeneration, with adverse effects of learning and behavior, according to the researchers
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